Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore
نویسندگان
چکیده
منابع مشابه
Axonal degeneration is mediated by the mitochondrial permeability transition pore.
Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Several signaling pathways are implicated in axonal degeneration, but identification...
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Sebastian A. Barrientos,1* Nicolas W. Martinez,1* Soonmoon Yoo,2 Juan S. Jara,1 Sebastian Zamorano,3 Claudio Hetz,3,4,5 Jeffery L. Twiss,6 Jaime Alvarez,1 and Felipe A. Court1,5 1Department of Physiology, Faculty of Biology, Catholic University of Chile, Santiago 8331150, Chile, 2Nemours Biomedical Research Institute, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19716, 3Institut...
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This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D. In particular, covalent labelling of CyP-D in situ by a photoactive CsA derivative has shown that pore ligan...
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Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during earl...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2011
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.4065-10.2011